Post-translational modifications (PTM) by members of the ubiquitin family are at the heart of almost every biological process, including regulation of protein levels, localization, and quality control. Defects in this protein homeostasis (proteostasis) can result in developmental anomalies and disease. An intricate interplay exists among the ubiquitin-family members, with diverse chains and linkages that constitutes a “ubiquitin code”, the full meaning of which is largely unknown. Fundamental research on the ubiquitin code continues to grow, with the pharmaceutical industry taking aim at potential targets in the proteostasis area for novel therapies.


 “Writing and Editing the Ubiquitin Code” is a one-and-a-half day symposium that will focus on how the code is written and edited through ligases and proteases, how the different modifications affect cell signaling, and how new technologies can be applied to analyze these modifications. Presentations will cover a wide range of topics, from genome instability and metabolic regulation, to cancer, neurodegeneration and infectious diseases.


ABSTRACT SUBMISSION: 01 AUG. 2019 - 10 JAN. 2020

Click here to register or submit an abstract


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UPV/EHU          CIC bioGUNE            CNRS


The University of the Basque Country / Euskal Herriko Unibertsitatea (UPV-EHU) is an integrating institution willing to produce knowledge, experience and research in order to forward them to the general public. The university research groups participates in various public and private projects. In addition, UPV-EHU collaborates with research centers, companies and institutions for the transfer of research results, scientific and technological cooperation and the establishment of strategic alliances in R&D.

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CIC bioGUNE is a key research center within the national and international scientific landscape and has emerged as a knowledge source in the area of health science. The cutting-edge scientific activity of CIC bioGUNE researchers explores the interface between Chemistry and Biomedicine, with emphasis on Structural, Molecular and Cell Biology. Two research programmes - "Molecular Recognition and Host-Pathogen Interactions" and "Metabolism and Cell Signaling in Disease" – are made up of more than a hundred scientists and technicians who concentrate on the molecular bases and mechanisms of disease to create new diagnostic methods and promote development of advanced therapies.

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The French National Centre for Scientific Research (CNRS) is among the world's leading research institutions. Its scientists explore the living world, matter, the Universe, and the functioning of human societies in order to meet the major challenges of today and tomorrow. Internationally recognised for the excellence of its scientific research, the CNRS is a reference in the world of research and development, as well as for the general public.

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UbiCODE                UBIRED              TRIM


The UbiCODE Innovative Training Networkis composed of 11 research institutions across 5 countries in the EU conducting world-class research in post-translational modifications with ubiquitin and ubiquitin-like molecules. This European programme aims to train a new generation of creative, entrepreneurial and innovative early-stage researchers, able to face current and future challenges and to convert knowledge and ideas into products and services for economic and social benefit.

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This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 765445.


UBIRed is a network committed to improve the quality, productivity and impact of the research groups in Spain specialised in the study ofubiquitin and UBL proteins and their roles in cell proliferation, differentiation and cancer. The expected impact of UBIRed is to develop strategies aiming at modulating UBL modification processes to better diagnose and/or cure those cancers in which UBLs conjugation is involved. In this manner, we expect to increase Spanish scientific leadership in this highly competitive field and to translate scientific knowledge into cutting-edge innovations that will improve human health.

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The TRIM-NET consortium is designed to bring together a multidisciplinary team that connects different expertise (genetics, biochemistry, molecular and cell biology, chemical biology, structural biology) across Europe to address TRIM proteins activity and to develop novel therapeutics for the treatment of different types of cancer, rare genetics diseases, neuromuscular pathologies, and neurodegenerative diseases.

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